CMI Industries workers in Campbellfield were in shock after the company announced 64 jobs would be slashed by October.
The business, which went into administration in April, will close after receivers failed to find a buyer.
The news comes a week after Ford announced 220 job would go from its Broadmeadows plant by November. And that was in addition to 240 Ford job cuts last year.
CMI makes seatbelt restraints, airbags, brake pad backing plates, suspension components, and door and boot hinge parts used in Ford cars.
Australian Manufacturing Workers Union secretary Leigh Diehm said CMI workers were "working through the process; they're still in a state of shock".
He said all the sacked workers lived in the Hume area and it would be hard for them to find work given the number of redundancies made in the area of late.
"It's going to be hard given this is happening no more than a week after Ford Broadmeadows made its redundancies.
"It's a really hard time for people in Hume. There will be a cluster of people looking for jobs. Geographically, it's not good for that whole area."
Calwell MP Maria Vamvakinou said she was saddened by the job losses.
"The country is working through changes that come with a two-speed economy, which means some industries are thriving while others are facing serious challenges."